• Initial Protocol: Typically administered 1-2 times per week during active treatment for a specific condition, such as chronic inflammation or metabolic support.
• Maintenance Protocol: Reduced to 1-2 times per month for general wellness and preventive care.
• Treatment frequency will be personalized based on the individual’s health goals, condition, and response to therapy.

1. Antioxidant Properties: EGCG neutralizes reactive oxygen species (ROS), preventing damage to lipids, proteins, and DNA. It also boosts the activity of endogenous antioxidants like superoxide dismutase (SOD) and glutathione peroxidase.

2. Anti-inflammatory Effects:

• Inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6).
• Reduces NF-κB signaling, a key pathway in chronic inflammation.

3. Metabolic Effects:

• Fat metabolism: EGCG activates AMP-activated protein kinase (AMPK), promoting fat oxidation and energy expenditure.
• Insulin sensitivity: Improves glucose uptake in cells by enhancing GLUT4 translocation.

4. Anti-cancer Effects:

• Inhibits angiogenesis (formation of new blood vessels in tumors).
• Induces apoptosis (programmed cell death) in cancer cells without harming normal cells.
• Interferes with the cell cycle, particularly at the G1 phase, halting tumor growth.

5. Neuroprotection:

• Reduces amyloid-beta plaque formation in the brain, potentially slowing Alzheimer’s progression.
• Protects neurons from oxidative damage and inflammation.

6. Cardiovascular Protection:

• Improves endothelial function and nitric oxide production, promoting healthy blood vessel dilation.
• Reduces LDL oxidation and enhances HDL cholesterol levels.

7. Detoxification: Enhances liver function by activating detoxification enzymes (e.g., glutathione-S-transferase)

• Cancer Adjunct: EGCG IV stands out as a supportive therapy for cancer due to its targeted anti-cancer mechanisms.
• Fat Metabolism: Unique benefits for metabolic health and weight management.

• Neuroprotection: Offers better brain health support compared to traditional IV therapies.

Here are some key findings from clinical research supporting the use of EGCG, particularly in intravenous form or high doses:

1. Anti-Cancer Benefits

• Study on Tumor Inhibition:
• EGCG has been shown to inhibit cancer cell proliferation by interfering with cell cycle regulation and inducing apoptosis.
• A study published in Cancer Letters (2019) demonstrated that EGCG suppressed angiogenesis (new blood vessel formation) in tumors and reduced tumor size in animal models.
• Key Insight: Its selective cytotoxicity ensures cancer cells are targeted, while healthy cells remain unharmed.
• Synergy with Chemotherapy:
• Research in Clinical Cancer Research (2020) highlighted that EGCG enhances the effectiveness of certain chemotherapeutic agents, such as doxorubicin, by sensitizing cancer cells to treatment.

2. Metabolic Support and Weight Loss

• Study on Fat Oxidation:
• A study in The American Journal of Clinical Nutrition (2016) showed that high doses of EGCG increase fat oxidation by 33% during moderate-intensity exercise in humans.
• Relevance to IV Use: Higher bioavailability via IV administration could enhance fat metabolism for weight management.
• Improved Insulin Sensitivity:
• EGCG was found to lower fasting blood glucose levels and improve insulin sensitivity in a trial on patients with metabolic syndrome (Journal of Medicinal Food, 2018).
• IV EGCG could be particularly beneficial for diabetic or prediabetic patients.

3. Neurological Protection

• Reduction of Alzheimer’s Progression:
• Studies, such as one published in Neurobiology of Aging (2021), have shown EGCG reduces amyloid-beta plaque formation in the brain, a hallmark of Alzheimer’s disease.
• Potential with IV Use: Enhanced delivery to brain tissues could make it more effective for neuroprotection.
• Parkinson’s Disease:
• EGCG’s neuroprotective effects have been linked to the inhibition of dopaminergic neuron loss in studies with animal models (Frontiers in Aging Neuroscience, 2020).

4. Cardiovascular Health

• Cholesterol and Blood Pressure Reduction:
• A meta-analysis published in The Journal of Nutrition (2017) found that EGCG reduced LDL cholesterol by an average of 9% and systolic blood pressure by 2–4 mmHg.
• IV administration could provide faster cardiovascular support, especially for individuals with high oxidative stress or inflammation.

5. Detoxification and Liver Support

• Liver Health:
• A study in Hepatology (2018) demonstrated that EGCG reduces liver fat accumulation and improves liver enzyme levels in patients with non-alcoholic fatty liver disease (NAFLD).
• Relevance to IV Use: Direct delivery may enhance detox pathways more effectively than oral EGCG.

EGCG IV therapy is generally safe but may not be suitable for everyone.

Contraindications include:

1. Liver Dysfunction: High doses of EGCG may exacerbate liver damage in susceptible individuals.
2. Pregnancy and Breastfeeding: Safety in these populations has not been fully established.
3. Bleeding Disorders: EGCG can interfere with platelet aggregation and blood clotting.
4. Cardiac Arrhythmias: High doses may impact heart rhythm.
5. Drug Interactions:

• Anticoagulants (e.g., warfarin) due to increased bleeding risk.
• Chemotherapeutic Agents: Potential interactions that may enhance or reduce effectiveness.
• Beta-blockers: Possible interference with cardiovascular effects.

6. Hypersensitivity: Individuals with allergies to tea or related compounds should avoid it.

Potential Drawbacks

• EGCG IV is less effective for immediate hydration or acute energy boosts compared to therapies like Liquid Money or NAD+ IV.
• More specific in action, making it less of a “general wellness” option compared to Vitamin C or Glutathione IV.